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. 2002 Dec;1(6):978–986. doi: 10.1128/EC.1.6.978-986.2002

TABLE 1.

Genes that are upregulated by a factor of 2 or more in response to a disruption of the PEX12 genea

Gene ORFb Extent of upregulation (factor) Function PTS Lysine-auxotroph?
LYS9 YNR050C 5.06 Saccharopine dehydrogenase -SLx5HP- Yes
LYS20 YDL182W 3.96 Homocitrate synthase Yes
CTP1 YBR291C 3.39 Citrate transporter (mitochondrial) Partially†
LYS4 YDR234W 2.99 Homoaconitase -SQL* Yes
SNO1 YMR095C 2.83 Stationary-phase induced gene No
YJL200C YJL200C 2.74 Aconitase homologue Partially†
LYS1 YIR034C 2.56 Saccharopine dehydrogenase -SRL* Yes
LYS12 YIL094C 2.47 Homoisocitrate dehydrogenase -SRL Yes
YBR147W YBR147W 2.45 STM1-homologue, 7-TM nitrogen starvation sensor No
SNZ1 YMR096W 2.26 Stationary-phase induced gene No
YDL183C YDR183C 2.07 Uncharacterized No
LYS21 YDL131W 1.64 Homocitrate synthase Yes
LYS2 YBR115C 1.57 Aminoadipate semialdehyde dehydrogenase -KLx5HL- Yes
LYS5 YGL154C 1.17 Lys2p-phosphopantetheinyl transferase Yes
a

For reference, three other genes involved in lysine biosynthesis are shown at the bottom of the table. Functional properties according to the Saccharomyces Genome Database (http://genome-www.stanford.edu/Saccharomyces/). PTS, predicted peroxisomal targeting signal. Peroxisomal targeting has been shown by GFP fusion (14) and is indicated by an asterisk. The doubling time is increased by ca. 150% in YJL200C-disrupted and 10% in CTP1-disrupted yeast in lysine-deficient medium and is indicated by a dagger.

b

ORF, open reading frame.

HHS Vulnerability Disclosure