Table 4.

Common side-effects reported in two tamoxifen chemoprevention trials

Side effect	Trial	Tamoxifen (%)	Placebo (%)	P
Hot flushes	RMH	34	20	<0.001
	NSABP	78	65	<0.001
Vaginal discharge	RMH	16	4	<0.001
	NSABP	55	34	<0.001
Menstrual	RMH	14	9	0.002
Irregularities (bleeding)	NSABP	22	21	NS
Nausea	RMH	6	10	0.02
Headaches	RMH	12	14	NS
Mood change	RMH	3	3	NS
	NSABP	11	12	NS
Weight gain/loss	RMH	7	11	NS
	NSABP	45	42	NS

NS, not significant. Data for the RMH trial from [13]; Data for the NSABP study from [3*,14].