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. Author manuscript; available in PMC: 2006 Mar 3.
Published in final edited form as: Nature. 2005 Apr 7;434(7034):767–772. doi: 10.1038/nature03419

Figure 1. The sst1 locus mediates innate immunity to tuberculosis.

Figure 1

a, b, Survival of C3H, B6, and the C3H.B6-sst1 (sst1R) mice after i.v. (a) or aerosol (b) infection with MTB; c, MTB bacterial loads in the lungs of the sst1 congenic mice after the aerosol infection; d, e Tuberculosis lung lesions 25 days after i.v. infection (d) and 12 weeks after aerosol infection, H&E, 40X original magnification (e); f, FACS analysis of mechanism of cell death of the sst1 congenic macrophages infected with MTB (top panels) or BCG (bottom panels) in vitro; g, Multiplication of MTB (left panel) or M. bovis BCG (right panel) in the sst1 congenic macrophages in vitro (*p<0.01, **p<0.001). Error bars represent 95% confidence intervals.