Table 2.
Area under receiver operator curve, sensitivity, specificity, positive predictive value, and negative predictive value of alcohol use disorders identification test (AUDIT), γ-glutamyltransferase (GGT), per cent carbohydrate deficient transferrin (%CDT), aspartate aminotransferase (ASAT), and erythrocyte mean cell volume (MCV) for hazardous alcohol use, monthly binge consumption, weekly binge consumption, and dependence in 194 male attendees in primary care
| Variable | P value for logistic regression | P value after controlling for AUDIT score* | Area under curve | Sensitivity % (95% CI†) | Specificity % (95% CI†) | Positive predictive value % (95% CI†) | Negative predictive value % (95% CI†) |
|---|---|---|---|---|---|---|---|
| Hazardous alcohol use: | |||||||
| AUDIT (≥8) | <0.001 | — | 0.94 | 69 (57 to 81) | 98 (97 to 100) | 95 (91 to 99) | 86 (78 to 94) |
| GGT (>55 IU/I) | 0.06 | 0.01 | 0.64 | 37 (26 to 47) | 72 (62 to 83) | 41 (28 to 54) | 69 (61 to 77) |
| ASAT (>50 IU/I) | 0.09 | 0.3 | 0.53 | 20 (11 to 29) | 80 (71 to 89) | 34 (19 to 50) | 66 (59 to 73) |
| %CDT (>2.5%) | <0.001 | 0.7 | 0.68 | 47 (36 to 58) | 71 (60 to 82) | 46 (34 to 58) | 72 (64 to 80) |
| MCV (≥95 fl) | 0.03 | 1.0 | 0.62 | 32 (21 to 43) | 71 (60 to 82) | 36 (23 to 50) | 67 (59 to 74) |
| Monthly binge consumption: | |||||||
| AUDIT (≥8) | <0.001 | — | 0.96 | 66 (54 to 78) | 97 (95 to 99) | 91 (86 to 97) | 84 (76 to 92) |
| GGT (>55 IU/I) | 0.06 | 0.08 | 0.62 | 42 (31 to 54) | 76 (65 to 86) | 49 (34 to 63) | 71 (63 to 78) |
| ASAT (>50 IU/I) | 0.08 | 0.3 | 0.55 | 26 (16 to 37) | 82 (73 to 92) | 45 (27 to 63) | 67 (60 to 74) |
| %CDT (>2.5%) | <0.001 | 0.3 | 0.73 | 59 (48 to 71) | 76 (66 to 86) | 57 (44 to 71) | 78 (70 to 85) |
| MCV (≥95 fl) | 0.002 | 0.2 | 0.64 | 36 (24 to 47) | 71 (60 to 82) | 40 (26 to 54) | 67 (59 to 75) |
| Weekly binge consumption: | |||||||
| AUDIT (≥8) | <0.001 | — | 0.94 | 75 (61 to 90) | 90 (88 to 93) | 71 (63 to 80) | 92 (86 to 98) |
| GGT (>55 IU/I) | 0.1 | 0.7 | 0.62 | 44 (32 to 57) | 74 (64 to 83) | 35 (22 to 47) | 81 (75 to 86) |
| ASAT (>50 IU/I) | 0.004 | 0.2 | 0.49 | 29 (16 to 42) | 82 (74 to 90) | 34 (17 to 50) | 78 (73 to 84) |
| %CDT (>2.5%) | 0.002 | 0.7 | 0.72 | 61 (49 to 74) | 71 (62 to 81) | 41 (29 to 53) | 85 (80 to 91) |
| MCV (≥95 fl) | 0.04 | 0.5 | 0.59 | 31 (19 to 43) | 69 (59 to 79) | 24 (14 to 35) | 76 (69 to 82) |
| Alcohol dependence: | |||||||
| AUDIT (≥8) | <0.001 | — | 0.94 | 84 (66 to 100) | 83 (81 to 86) | 41 (32 to 50) | 97 (94 to 100) |
| GGT (>55 IU/I) | 0.5 | 0.004 | 0.59 | 32 (18 to 45) | 69 (61 to 78) | 13 (7 to 18) | 88 (83 to 93) |
| ASAT (>50 IU/I) | 0.4 | 0.04 | 0.50 | 19 (8 to 30) | 80 (72 to 88) | 12 (5 to 19) | 88 (83 to 92) |
| %CDT (>2.5%) | 0.03 | 0.7 | 0.70 | 57 (41 to 73) | 68 (59 to 76) | 20 (12 to 28) | 92 (88 to 96) |
| MCV (≥95 fl) | 0.5 | 0.2 | 0.57 | 28 (15 to 41) | 70 (61 to 79) | 11 (6 to 17) | 87 (83 to 93) |
*
AUDIT P<0.001 in all regressions.
†
Large sample estimates approximate for intervals including zero or 100%.