Figure 1.

An alignment of the Epc-N domains from representative sequences of each of the four identified Epc-N protein subfamilies (I-IV). The alignment was constructed as described in the text. Secondary structure is defined by arrows (β-type extended strands) and bars (α-helices) and is annotated based on results from Jpred and corroborated by various prediction algorithms at the Polish metaserver [52]. The presumed ligands (20 total) of the PZPM found as part of the Epc-N domain in subfamily III and IV proteins are as shown.