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. 2006 Feb 15;3:13. doi: 10.1186/1742-4690-3-13

Figure 1.

Figure 1

Genomic structure of self-inactivating lentiviral vectors that lack or contain PCE translation enhancer. HIV-1 based lentiviral vectors were derived from pHR' [36]. Black rectangles represent HIV-1 long terminal repeats; PBS, primer binding site; Ψ, the core packaging signal; extended packaging signal that corresponds to 350 nt HIV-1 gag open reading frame; 5'ss and 3'ss, splice sites; RRE, Rev responsive element; PPT, polypurine tract; Δ indicates deletion of HIV-1 promoter sequences between -418 to -18; white boxes represent SNV sequences; Prom corresponds to spleen necrosis virus (SNV) U3 promoter; PCE is the 165 nt RU5 region of SNV; CMV IE, cytomegalovirus immediate early enhancer.