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Combinatorial library of cis-acting antigenomic delta ribozyme (inset) and a scheme of the selection-amplification procedure used to search for its catalytically active variants. The randomized regions are boxed. Numbering of nucleotides corresponds to the wild-type ribozyme sequence and nucleotide changes are shown in lower case letters. Base paired segments are denoted P1–P4 and the catalytic cleavage site is marked by the filled triangle.
