Table 3.
Human chromosome 21 centromere-proximal genes
| (a) Genes proximal to APP | (b) Genes from APP to SOD1 | ||
| Gene | Classification | Gene | Classification |
| Pred 65 | Zn finger | APP | |
| Pred 3 | Keratinocyte growth factor | Pred24 | |
| Pred 4 | Similar to KIAA1074 | ADAMTS1 | Metalloproteinase |
| orf15 | EST | ADAMTS5 | Metalloproteinase |
| Pred5 | Lipase | Pred25 | Exon |
| RBM11 | RNA binding | Pred26 | Exon |
| Pred6 | Exon | orf23 | EST |
| STCH | Stress protein | Pred27 | Exon |
| SAMSN-1 | Similar to KIAA0790 | Pred28 | Methyltransferase |
| NRIP1 | Nuclear factor | ZNF294 | Zinc finger |
| USP28 | Ubiquitin protease | orf6 | EST |
| orf34 | EST | USP16 | Ubiquitin protease |
| orf35 | EST | CCT8 | T-complex subunit |
| orf36 | EST | orf7 | Exon |
| orf37 | EST | Bach1 | Transcription factor |
| CXADR | Viral receptor | orf12 | EST |
| BTG3 | Cell cycle control | orf8 | EST |
| YG81 | CDNA | GRIK1 | Glutamate receptor |
| orf39 | EST | Orf41 | EST |
| Pred12 | Mannose receptor | orf9 | EST |
| PRSS7 | Enterokinase | CLDN17 | Claudin receptor |
| orf40 | EST | CLDN8 | Claudin receptor |
| NCAM2 | Neural adhesion | Pred29 | Exon |
| Pred15 | Exon | Pred30 | Exon |
| Pred16 | EST | TIAM1 | Lymphoma metastasis |
| orf53 | EST | Pred 31 | Exon |
| orf42 | EST | SOD1 | |
| Pred21 | EST | ||
| Red22 | tRNA synthetase | ||
| orf43 | Junction adhesion | ||
| ATP5A | ATPase factor | ||
| GABPA | Transcription factor | ||
(a) Mouse homologs possibly disomic in both Ts65Dn and Ts1Cje. (b) Mouse homologs expected to be trisomic in Ts65Dn but disomic in Ts1Cje.