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. 2004 Mar;123(3):295–304. doi: 10.1085/jgp.200308925

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Copyright © 2004, The Rockefeller University Press

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Figure 3. — Voltage dependence of block in CNGA1 and CNGA2 channels. (A) Block of CNGA1 channels by 50 nM dequalinium in the presence of 2 mM cGMP (filled circles) or 32 μM cGMP (open circles). The curves represent fits with Scheme I, with K_Do = 4 μM and K_Dc = 1.3 μM. The value of zδ was 1 in both cases. (B) Block of CNGA2 channels by 500 nM dequalinium in the presence of 2 mM cGMP (filled circles) or 1.8 μM cGMP (open circles). The curves represent fits with Scheme I, with K_Do = 20 μM, and K_Dc = 3.6 μM The value of zδ was 1 in both cases. Dequalinium concentrations below the IC₅₀ of block were used since otherwise block at depolarized potentials becomes rapidly saturated and the voltage-dependence of block cannot be correctly determined.