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. 2004 Mar;123(3):295–304. doi: 10.1085/jgp.200308925

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Copyright © 2004, The Rockefeller University Press

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Figure 5. — cGMP activation curves for S4/S5-chimeras. (A and C) Activation of the S4/S5-CNGA1 and S4/S5-CNGA2 chimeras by cGMP. Data were fit with Eq. 1 (see materials and methods). The dashed lines represents the activation curve for wild-type CNGA1 (A) and CNGA2 channels (C). The K_1/2 for activation by cGMP was 66 μM for S4/S5-CNGA1 and 2.6 μM for S4/S5-CNGA2. (B and D) Fractional activation by cAMP (thin traces) was of ∼6% of the maximal current activated by cGMP (thick traces) for both wild-type CNGA1 (B, left) and S4/S5-CNGA1 channels (B, right), and 86% for wild-type CNGA2 (D, left) and S4/S5-CNGA1 (D, right)