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. 2004 Mar;123(3):295–304. doi: 10.1085/jgp.200308925

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Copyright © 2004, The Rockefeller University Press

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Figure 6. — Voltage dependence of block in S4/S5-CNGA1 and S4/S5-CNGA2 channels. (A) Block of S4/S5-CNGA1 channels by 50 nM dequalinium in the presence of 2 mM cGMP (filled circles) and 32 μM cGMP (open circles). The curves represent fits with Scheme I, with K_Do = 4 μM and K_Dc = 250 nM. (B) Block of S4/S5-CNGA2 channels by 500 nM dequalinium in the presence of 2 mM cGMP (filled circles) and 1.8 μM cGMP (open circles). The curves represent fits with Scheme I, with K_Do = 14 μM and K_Dc = 300 nM.