Table 1.
Pharmacokinetic parameters for gemcitabine summarized from published data (Abbruzzese et al., 1991; Bhargava et al., 2001; Kroep et al., 1999), infusion at a rate of 10 mg/(m2·min) (1000 mg/m2, 30-min infusion) and calculated for 6 Chinese NSCLC subjects after infusion at a rate of 10 mg/(m2·min) (1200 mg/m2, two hours infusion)
| Pharmacokinetic parameters | x¯±SD | Reported data |
| Ke (min−1) | 0.07±0.02 | |
| t1/2 (min) | 10.67±3.38 | 9–22.3 |
| Cmax (μg/ml) | 4.92±1.79 | 10.0–18.3 |
| AUCtn ((μg·h)/ml) | 7.55±1.53 | 7.5–11.4 |
| CL (ml/min) | 3940.05±672.08 | 2550–4080 |
| MRT (min) | 88.99±9.86 |