Table 2.
Mouse and human granzymes grouped according to their chromosomal localization
Chromosomal localization | Species | Granzyme(s) |
The 'tryptase' locus | ||
5q11-q12 | Human | A and tryptase-2 |
13D | Mouse | A |
The 'chymase' locus | ||
14q11-q12 | Human | B and H |
14D | Mouse | B,C,D*,E,F and G* |
The 'Met-ase' locus | ||
19p13.3 | Human | M |
10q21.2 | Mouse | M |
*Granzymes D and G have not been definitively mapped, but are highly homologous to granzymes E and B, respectively.