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. 2006 Mar 3;34(5):1342–1350. doi: 10.1093/nar/gkl022

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© The Author 2006. Published by Oxford University Press. All rights reserved

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Targeting ZBP-89 exon 4 in mice. (A) Replacement of exon 4 with a Neomycin resistance cassette (NEO) by homologous recombination in ES cells. Top panel: bracket shows location of features encoded by exon 4, including initiation codon, acidic domain (black rectangle) and p300 interaction domain. Open boxes, basic domains; hatched boxes, zinc-fingers; stippled region, untranslated. Middle panel; Zfp148 genomic locus. Intron sizes (kb) are shown. Lower panel; targeting strategy. (B) Tail biopsy DNA genotyping. WT (Int 3 F/Int 4 R) and Δexon4 (Int 3 F/Neo R) amplimers. (C) Near-Mendelian inheritance of ΔExon-4 alleles. The differences between predicted and observed values were not significant.