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Analysis of pathway implication on human breast cancer metastasis. (A) Pathway model. a, Active Akt1 phosphorylates TSC2, stimulating down-modulation of TSC2 levels; b, TSC2 activates Rho; c, Active Rho promotes cytoskeletal rearrangements permissive for cell invasion. (B) Metastasis-free survival of human breast tumors stratified by expression of Akt1 and TSC2. Higher expression of TSC2 together with low expression of Akt1 is predictive of decreased time to metastasis in breast tumors.
