Fig. 8. The mitochondrial Ca2+ uptake inhibitor ruthenium red reduces the ability of ICRAC to activate in weak intracellular Ca2+ buffer following store depletion with thapsigargin. (A) The time course of activation of ICRAC is compared between a control cell (filled circles; dialysed with thapsigargin and 0.1 mM EGTA) and one in which ruthenium red (100 µM) had been added to this pipette solution (open circles). (B) Aggregate data for the two conditions are summarized [nine cells for control and eight for ruthenium red (RuR)].