Fig. 4. Positions of seven suvh4 alleles recovered as PAI2 silencing suppressors. The predicted amino acid sequence of WS SUVH4 is shown, with the positions of introns marked with black arrowheads. Missense mutations are indicated by the new amino acid above the affected codon. Nonsense mutations are indicated by an asterisk above the affected codon. Splice mutations are indicated by an x at the appropriate junction of the affected intron. The YDG, pre-SET, SET and post-SET domains as previously defined for SUVH4 relative to related proteins (Baumbusch et al., 2001; Jackson et al., 2002) are underlined. The WS genomic sequence of SUVH4 is available as DDBJ/EMBL/GenBank accession No. AF538715.