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Model system for single nucleotide polymorphism detection. SNP primer was annealed as indicated to the test sequence containing a polymorphic site at the underlined position. In the presence of a DNA polymerase and four ddNTPs, the primer is extended by a single base complementary to the polymorphic site. When subjected to DE-MALDI-TOF, the difference in mass between unextended and extended primer indicates which bases were added.
