Fig 1.

Schematic model for the photoresponsive enzyme switch. The photoresponsive copolymer compositions are shown with the end-modified vinyl sulfone terminus for thiol-specific conjugations. The 3D model of EG 12A displays the relative locations of position 55 (colored green with schematic polymer coil attached) and the catalytic active site residues D99, E116, and E200 shown in red. The ONPC substrate is shown schematically to show the orientation of the active site groove. The polymer coil is shown as a 10-kDa chain with a distribution of nine DMA monomers to one azobenzene monomer.