Skip to main content
. 2006 Mar 17;2(3):e18. doi: 10.1371/journal.pcbi.0020018

Figure 6. CPHL1, a Novel Ceruloplasmin-Like Gene.

Figure 6

Standard UCSC Genome Browser view of the CP locus showing a 90-kb “desert” separating it from the next known gene, LOC116441, and GESTALT view of the same locus, indicating the extent of the transcribed region predicted by ROAST (red bar in ROAST track) and the predicted gene structure for CPHL1. Interspersed repeats are color-coded, with red, green, pink, and brown bars representing Alu, MIR, LINE, and other repeats, respectively, and bar height indicating repeat age (younger repeats are taller); the megabase scale starts at the p telomere. The newly discovered gene overlaps with a gene structure predicted by Twinscan (chr3.151.005.a) but shares only seven of 21 exons, one imprecisely. GenScan predicts a much longer structure continuous with the CP gene, sharing 14 exons with CPHL1, of which ten are precisely predicted.

Inset: Phylogenetic analysis of the CP/CPHL1 family rooted using the hephaestin protein sequence as outgroup. Numbers above branches represent percentage bootstrap support over 1,000 replicates; the horizontal bar indicates 10% divergence along each branch.