TABLE 2.
Main analysis results based on multiple assays (manufacturers) and on the most popular assay and sensitivity analysis resultsa
| Assay(s) | tTG type | No. of assays or studies | No. of cases/no. of controls | % Se (95% CI) | % Sp (95% CI) | a (95% CI) | b (95% CI) | AUC | pSe (%) | Q* (%) (95% CI) |
|---|---|---|---|---|---|---|---|---|---|---|
| All | rh | 20 assays | 1,602/2,210 | 94 (90, 96) (RE) | 95 (93, 97) (RE) | 6.70 (5.74, 7.65) | 0.08 (−0.51, 0.68) | 0.99 | 100 | 97 (96, 97) |
| 88 (86, 90) (FE) | 94 (93, 95) (FE) | |||||||||
| ph | 7 assays | 257/362 | 94 (87, 97) (RE) | 94 (88, 97) (RE) | 6.33 (4.70, 7.97) | 0.04 (−1.04, 1.13) | 0.99 | 100 | 96 (94, 98) | |
| 91 (86, 95) (FE) | 94 (89, 95) (FE) | |||||||||
| gp | 21 assays | 1,462/2,115 | 91 (87, 94) (RE) | 89 (81, 94) (RE) | 4.99 (4.31, 5.66) | −0.22 (−0.49, 0.05) | 0.97 | 97 | 92 (91, 94) | |
| 87 (85, 89) (FE) | 87 (85, 89) (FE) | |||||||||
| Most popular | rh | 13 studies | 1,120/1,500 | 94 (92, 96) (RE) | 97 (95, 98) (RE) | 7.20 (5.94, 8.45) | −0.08 (−0.94, 0.78) | 0.99 | 100 | 97 (97, 98) |
| 94 (92, 95) (FE) | 96 (94, 97) (FE) | |||||||||
| ph | 5 studies | 176/288 | 92 (83, 97) (RE) | 96 (90, 99) (RE) | 6.70 (3.54, 9.86) | 0.25 (−2.30, 2.80) | 0.99 | 100 | 97 (94, 99) | |
| 90 (83, 94) (FE) | 95 (91, 97) (FE) | |||||||||
| gp | 15 studies | 1,168/1,911 | 90 (84, 94) (RE) | 92 (86, 96) (RE) | 5.17 (4.26, 6.09) | −0.08 (−0.52, 0.35) | 0.98 | 98 | 93 (91, 95) | |
| 87 (84, 89) (FE) | 90 (89, 92) (FE) | |||||||||
| Most popular (sensitivity analysis) | rh | 11 studies | 948/1,262 | 94 (92, 96) (RE) | 96 (94, 98) (RE) | 6.89 (5.88, 7.90) | −0.16 (−0.82, 0.5) | 0.99 | 99 | 97 (96, 98) |
| 94 (92, 95) (FE) | 96 (94, 97) (FE) | |||||||||
| ph | 4 studies | 144/250 | 95 (82, 97) (RE) | 98 (95, 99) (RE) | 7.66 (5.91, 9.41) | 0.61 (−0.65, 1.87) | 0.99 | 100 | 98 (97, 99) | |
| 91 (83, 95) (FE) | 98 (95, 99) (FE) | |||||||||
| gp | 14 studies | 1,136/875 | 91 (87, 94) (RE) | 93 (87, 96) (RE) | 5.48 (4.81, 6.14) | −0.15 (−0.46, 0.16) | 0.98 | 98 | 94 (93, 95) | |
| 88 (86, 90) (FE) | 91 (90, 93) (FE) |
a
The independent pooled sensitivity (Se) and pooled specificity (Sp) using RE and FE models, the intercept and slope of the unweighted SROC curve, the AUC of the SROC curve, the pSe derived from SROC using the RE Sp, and the Q* point where sensitivity and specificity are equal are shown.