FIGURE 4.

TGF-β1 inhibits IgE-mediated up-regulation of FcεRI surface expression. BMMC were cultured for 4 days in the presence or the absence of IgE (1 μg/ml). On day 4 of culture, cells were fed, and TGF-β1 (5 ng/ml) was added to one set of samples containing IgE for 3 days. Surface FcεRI expression was assessed by flow cytometry. Data shown are one representative histogram from seven BMMC populations that gave similar responses.