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Alignment of archaeal-type Pth2 proteins. Sequences from the archaea M. jannaschii, P. furiosus, S. solfataricus, and A. pernix lack the highly diverged N-terminal domain found in eukaryal proteins from S. cerevisiae (YBL057c) and humans. Identical or highly conserved residues are shown in white against a black background, and similar residues are shown in black against a gray background. The beginning and the end of the UPF0099 domain are marked with arrows.
