Table 2.
BAL data from saline-treated and TiO2- and ROFA-exposed rats.
| BAL fluid
|
||||
|---|---|---|---|---|
| Experimental group | Cellular content of PMNL (106 cells/rat) | Albumin (mg/mL) | LDH (U/L) | Total AM CL |
| Saline control | 0.93 ± 0.11 | 0.13 ± 0.02 | 58 ± 10 | 7.50 ± 1.63 |
| 0.1 mg TiO2 | 1.73 ± 0.36* | 0.14 ± 0.04 | 67 ± 13 | 5.21 ± 1.60 |
| 0.1 mg ROFA | 1.24 ± 0.28 | 0.23 ± 0.05 | 75 ± 2 | 14.47 ± 2.60*,** |
| 0.25 mg TiO2 | 1.11 ± 0.15 | 0.19 ± 0.02 | 65 ± 8 | 3.64 ± 0.73 |
| 0.25 mg ROFA | 1.91 ± 0.20* | 0.17 ± 0.01 | 46 ± 4 | 17.42 ± 1.11*,** |
N = 22 rats for saline control; N = 5–7 rats for all other doses. Values are mean ± SE. CL = counts per minute × 105/0.25 × 106 AM/15 min.
*
p < 0.05 compared with saline.
**
p < 0.05 compared with 0.1 mg TiO2 and p < 0.05 compared with 0.25 mg TiO2.