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. 2002 Dec 16;99(26):16865–16870. doi: 10.1073/pnas.262499599

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Copyright © 2002, The National Academy of Sciences

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Fig 1. — Rb+/−;ARF−/− compound mutant mice exhibit significantly decreased survival relative to Rb+/− and Rb+/−;ARF+/− mice. Survival curves of Rb+/− (n = 37), Rb+/−;ARF−/− (n = 32), and Rb+/−;ARF+/− (n = 13) mice show that Rb+/−;ARF−/− mice had a significantly decreased median survival of 168.5 days vs. 277 days for Rb+/− controls (P < 0.0001). The Rb+/−; ARF+/− mice (n = 13) exhibited a median survival of 262 days, comparable to that of Rb+/− mice (P = 0.34) and significantly longer than that of Rb+/−; ARF−/− mice (P < 0.0001).