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. 2002 Dec 16;99(26):16865–16870. doi: 10.1073/pnas.262499599

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Fig 2. — Comparison of tumors of similar stage from Rb+/−;ARF−/− and Rb+/− mice shows higher levels of proliferation in Rb+/−;ARF−/− samples. Midsagittal sections of pituitary tumors (P) at comparable stages of development were stained with hematoxylin and eosin (A and B) or used for BrdUrd immunohistochemistry (C and D). Samples from a Rb+/− (6.5 months) mouse (A) and a Rb+/−;ARF−/− (4.5 months) compound mutant mouse (B) are shown. These animals were injected with BrdUrd (10 μg/kg body weight) 1 h before death, and analysis of BrdUrd incorporation demonstrated a significantly higher S-phase fraction (P < 0.05 for three matched pairs) in the Rb+/−; ARF−/− sample (D) relative to the Rb+/− control (C). (Calibration bar: 100 μm for A and B; 50 μm for C and D.)