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. 2002 Dec 16;99(26):16865–16870. doi: 10.1073/pnas.262499599

Fig 4.

Fig 4.

Tumors isolated from Rb+/−;ARF+/− animals exhibit alterations at the ARF locus. (A) DNA from normal adjacent cerebellum (con) confirms that the animals were heterozygous for Rb, and all samples of pituitary (pit) tumors showed LOH for Rb with only the 5.2-kB lower band associated with the mutant allele remaining. (B) DNA from normal adjacent cerebellum (con) confirmed that all of the animals were heterozygous for ARF. Of four pituitary samples that also showed this pattern of equivalent hybridization, two are shown here (pit 8566 and 8239). Two pituitary samples exhibited alterations at the ARF locus. These samples demonstrated enrichment for the lower 6.0-kB band associated with mutant allele (pit 8904 and 8249).