Fig 3.

Organization chart for incorporating LA with similarity-based methods. In this article, we only consider the use of a third gene to detect the LA activities. Coexpressed genes found by profile-similarity analysis can be pooled to obtain a consensus profile for LA scouting. Likewise, the genes identified through the LA system can be analyzed further for patterns of clustering. For some applications, the scouting variable may come from external sources related to the expression profiles. SVD, singular value decomposition; PCA, principal component analysis.