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DNMT3L stimulates de novo methylation by Dnmt3a at maternally methylated ICs and nonimprinted sequences. Key regions of the murine Snrpn IC (A) and murine Igf2r/Air IC (B) carried by pFC49 and pFC60, respectively, were introduced into cells together with expression vectors for Dnmt3a and/or DNMT3L, as indicated. (C) pCLH22, which carries the luciferase gene, was used. The probes used to detect methylation correspond to the respective ICs or to the luciferase gene.
