Fig 4.

Coexpression of Dnmt3a and DNMT3L results in extensive DNA methylation patterns. The percentage of CpG methylation observed at the SNRPN IC (A) or at the luciferase gene (B) was determined in individual molecules analyzed by bisulfite sequencing. Molecules were grouped into five classes depending on the percentage of methylation observed, as shown on the x axis. The fraction of each class within the total sample size is indicated on the y axis. Methylation of the target region resulted from Dnmt3a alone (gray bars) or Dnmt3a and DNMT3L together (black bars).