Fig 3.

IRF-1 is essential for IL-18BP expression in mice. Serum IL-18BP was measured in control C57BL/6 and C57BL/6 IRF-1^−/− mice that were injected i.p. with murine IFN-γ (53,000 units per mouse). Mice were bled before injection and 24 h postinjection, and serum IL-18BP was determined by ELISA. Data represent mean ± SD (n = 6 for each group). The differences between serum IL-18BP in control and IRF-1-deficient mice, as well as those between control and IFN-γ-induced C57BL/6 mice, were statistically significant (P < 0.05).