Table 6.
Leukaemia-related proteins containing multiple amino acid runs
| Gene, description | Chr | Amino acid runs | Disease association |
|---|---|---|---|
| ALK, anaplastic lymphoma kinase Ki-1 | 2 | G8 G5 G6 G6 | Important role in the development of the brain; anaplastic large cell lymphomas, caused by 2;5 translocation |
| BRD2, bromodomain-containing protein 2 | 6 | E6 E5 E5 S5 S11 | Mitogen-activated kinase, possibly part of a signal transduction pathway involved in growth control upregulated in certain leukemias |
| CREBBP, CREB-binding protein | 16 | Q5 Q18 | Augments the activity of phosphorylated CREB to activate transcription of cAMP-responsive genes Rubinstein-Taybi syndrome, leukemias |
| D6S51E, HLA-B-associated transcript-2 | 6 | P5 P5 G6 G6 P5 | Limited to cell lines of leukemic origin |
| KIAA0304 (MLL2) gene product | 19 | G5 P6 P5 P5 P5 Q5 P7 | Called trithorax homolog 2 (MLL2) in SWISS-PROT, but has little similarity to the other MLL2 gene in this list |
| LAF4, lymphoid nuclear protein 4 | 2 | S7 S5 S8 | Tissue-restricted nuclear transcriptional activator lymphoid tissue; acute lymphoblastic leukemia, Burkitt's lymphoma |
| MLL2, myeloid/lymphoid or mixed-lineage leukemia 2 | 12 | E5 A5 Q5 Q6 Q9 Q14 Q6 Q11 Q6 Q14 Q6 Q8 Q5 Q5 Q7 Q5 Q8 Q7 Q6 Q10 Q8 Q7 Q5 Q5 | Leukemia |
| MLLT6, trithorax (Drosophila) homolog | 17 | G6 G5 S11 A8 | Acute leukemias (by chromosomal translocations) |
| MN1, meningioma 1 | 22 | Q5 Q5 P5 Q28 P5 G5 G7 G5 | May play role in tumor suppression; highest expression in skeletal muscle; acute myeloid leukemia by a chromosomal translocation |
| ZNF220, zinc finger protein 220 | 8 | E6 E5 E5 E5 S6 P6 P7 | May represent a chromatin-associated acetyltransferase; acute myeloid leukemia (by translocation) |
CREB, cAMP response element-binding protein.