TABLE 1.
Response of pigs to intranasal infection with rgSw/ONT, rgSw/MN, rgSw/ONT+MN HA/NA, or rgSw/MN+ONT HA/NA
| Dose (TCID50) and virus | % Lung tissue consolidationa | HI antibody titer in seruma |
|---|---|---|
| None (controls) | 0.106 ± 0.0649 | 0 |
| 2 × 103 | ||
| rgSw/ONT | 0.53 ± 0.4744d | 4 ± 4c |
| rgSw/ONT+MN HA/NA | 12.65 ± 3.7452b,d | 36 ± 31.2 |
| rgSw/MN | 7.51 ± 3.37 | 92 ± 17.44b,c,d |
| rgSw/MN+ONT HA/NA | 5.194 ± 1.7332b | 0d |
| 2 × 106 | ||
| rgSw/ONT | 1.348 ± 1.0948c,d | 0c,d |
| rgSw/ONT+MN HA/NA | 16.614 ± 2.7937b,d | 324 ± 85.9b,d |
| rgSw/MN | 22.7 ± 5.4425b,c | 480 ± 101.2b,c,d |
| rgSw/MN+ONT HA/NA | 7.48 ± 5.1117 | 96 ± 29.9b,d |
a
Data are means ± SEM, n = 5 animals per treatment group.
b
P ≤ 0.05 versus controls.
c
P ≤ 0.05 between parental viruses at the given dose.
d
P ≤ 0.05 for parental virus versus HA/NA reassortant viruses.