Fig 5.

PMA augments the size of the asynchronous pool (AP) but not the synchronous pool (SP) of secretory granules. (A) Calcium currents and C_m response to a train of ten 100-ms depolarizing pulses from −70 to 0 mV. Traces displayed are from the same cell, before and 3 min after PMA treatment. The change of C_m in response to the first depolarization defines the SP size and the subsequent increase in C_m defines the AP. PMA increased AP by a factor of 2 (despite a reduction on calcium currents), but left SP unaltered. (B) Summary of the effect of PMA on SP and AP from six cells.