TABLE 1.

Activities of micafungin and caspofungin against 315 invasive clinical isolates of Candida spp. that are resistant to fluconazole^a

Organism (no. of isolates)	Antifungal	MIC (μg/ml)			Cumulative % of isolates susceptible at an MIC of (μg/ml):
		Range	50%	90%	0.03	0.06	0.12	0.25	0.5	1.0	2.0
C. albicans (41)	Micafungin	0.007-0.25	0.015	0.03	95	97	97	100
	Caspofungin	0.007-2.0	0.03	0.06	61	95	95	97	97	97	100
C. glabrata (110)	Micafungin	0.007-0.06	0.015	0.015	97	100
	Caspofungin	0.015-0.5	0.03	0.06	59	90	96	100
C. krusei (146)	Micafungin	0.007-.25	0.06	0.06	26	93	99	100
	Caspofungin	0.015-0.5	0.12	0.25	1	41	81	97	100
Candida spp. (18)	Micafungin	0.007-1.0	0.25	1.0	33	38	44	61	77	100
	Caspofungin	0.015-0.5	0.06	0.5	22	50	50	77	100
All Candida spp. (315)	Micafungin	0.007-1.0	0.03	0.06	60	93	96	97	98	100
	Caspofungin	0.007-2.0	0.06	0.25	30	66	86	97	99	99	100

^aResistance to fluconazole was indicated by a C. krusei or fluconazole MIC of >32 μg/ml.