Table 1.
Peak responses
| Voxel T
|
Voxel P (unc)
|
Atlas coordinates | Descriptive region name
|
ΔrCBF, %
|
||
|---|---|---|---|---|---|---|
| x | y | z | ||||
| 7.10 | 2 × 10−10 | 13 | 36 | 15 | R lateral orbital gyrus | −11.0 |
| 6.84 | 5 × 10−10 | −11 | 39 | 16 | L lateral orbital gyrus | −8.9 |
| 5.75 | 6 × 10−8 | 7 | 7 | 15 | R thalamus (LP/VLP) | −9.0 |
| 5.48 | 2 × 10−7 | −7 | 5 | 8 | L thalamus (pulvinar) | −9.0 |
| 5.43 | 2 × 10−7 | 22 | −1 | 16 | (Posterior) R superior temporal gyrus | −8.3 |
| 5.12 | 9 × 10−7 | −19 | 4 | 21 | L supramarginal gyrus | −6.0 |
| 5.11 | 10−6 | 4 | 6 | 26 | Posterior cingulate | −7.5 |
| 5.02 | 10−6 | 25 | 12 | 9 | R insula/superior temporal gyrus | −5.1 |
| 4.92 | 2 × 10−6 | 25 | 21 | 12 | R insula | −7.0 |
| 4.89 | 2 × 10−6 | −4 | 44 | 23 | (Medial) L superior frontal gyrus | −5.1 |
| 4.69 | 5 × 10−6 | 1 | 32 | 12 | (Subgenual) anterior cingulate gyrus | −7.8 |
Most significant local maxima (34), separated by >8 mm, in the region identified by spm as showing a significant decrease in rCBF with 500 μg/kg pramipexole i.v. after accounting for global effects. Voxel T, the t value computed at the given voxel; voxel P (unc), the P value corresponding to voxel T (87 d.f.) before correction for multiple comparisons; LP/VLP, lateral posterior nucleus/ventral lateral nucleus, pars postrema; ΔrCBF, mean change in rCBF from baseline in an 8-mm-diameter spherical region centered at the given coordinates.