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Overall synaptic vesicle turnover is intact in synaptojanin 1-deficient mice, but the functional recycling pool is 40% smaller. A plot of FM1-43 uptake ΔF (see text) as a function of AP number shows that knockout and control neurons have similarly shaped loading curves, both reaching maximal FM1-43 uptake with 600 APs. However, the absolute amount of trapped fluorescence in knockout synapses is 40% less than in control synapses.
