Fig 5.

Morphological features of epididymal spermatozoa from normal mice (A and D), NB-DNJ-treated mice (B and E, 15 mg/kg/day), and mice recovered from a 15 mg/kg/day NB-DNJ regimen (C). (A–C) Scanning electronmicrographs, showing examples of a normal head and midpiece (A), a spatulate sperm head with a disorganized squat mitochondrial sheath (B), and a normal head and midpiece after recovery from drug treatment (C). (D and E) Transmission electronmicrographs, displaying a normal spermatozoon (D) and a spermatozoon with alterations in nuclear shape, tail orientation, and morphology and arrangement of mitochondria (E). (Bar = 2 μm.)