Table 1.
Tissue weights and sperm counts
NB-DNJ, mg/kg/day
|
Weights, % | Counts, 106 | ||||
---|---|---|---|---|---|---|
Whole body | Testis | Caput + corpus | Cauda + vas | Sperm/testis | Sperm/cauda | |
0 | 100.0 ± 4.6 | 100.0 ± 6.7 | 100.0 ± 6.2 | 100.0 ± 7.3 | 17.8 ± 3.7 | 22.0 ± 3.8 |
15 | 95.2 ± 6.2 | 91.5 ± 8.0 | 91.5 ± 23.3 | 101.4 ± 15.1 | 14.1 ± 2.2 | 22.5 ± 6.7 |
150 | 95.7 ± 5.3 | 93.8 ± 5.2 | 99.2 ± 6.6 | 104.8 ± 8.2 | 15.1 ± 3.1 | 29.6 ± 10.3 |
1,200 | 69.1 ± 6.3 | 81.5 ± 6.9 | 74.8 ± 7.8 | 63.5 ± 13 | 14.5 ± 2.9 | 10.5 ± 3.1 |
2,400 | 59.5 ± 4.7 | 67.8 ± 9.3 | 59.2 ± 16 | 42.7 ± 6.7 | ND | ND |
Body and tissue weights are presented as percentages of the mean body and tissue weights from untreated animals, convenient for comparison of change in tissue weights with change in body weight in treated animals. The data are presented as the mean ± SD; for weights n = 10 and for counts n = 4. ND, not determined.
Significantly different from body weight (P < 0.05).
Significantly different from values obtained from untreated mice (P < 0.05).