FIG. 4.

Functional genomic organization of the MW2 chromosome compared with 15 clinical strains. From the outside inward, the first circle represents nucleotide position in Mbp. The second circle shows ORFs on the plus and minus (37) strands, with colors according to their COG functional categories. The third circle shows genetic mobile elements and virulence factors from MW2 (3). The fourth circle highlights gene targets that are absent from cluster D compared to MW2. The fifth, sixth, and seventh circles depict gene targets that are absent in clusters C, B, and A, respectively. The eighth circle represents G/C content of MW2. Roman numerals represent gene numbers that are further analyzed.