TABLE 2.
Sites of putative amino acid sequence differences in the HA and NA proteins of the H1N2 viruses described in this study
| Amino acid residuea | A/Swine/Ontario/ 52156/03b | A/Swine/Ontario/ 48235/04c | A/Swine/Ontario/ 55383/04c | PIRsd |
|---|---|---|---|---|
| HA 19 | P | T | T | |
| HA 42 | A | T | T | |
| HA 111 | Y | H | H | D |
| HA 145 | V | I | I | F |
| HA 158 | S | R | R | G |
| HA 414 | N | S | S | |
| HA 467 | S | G | G | |
| HA 541 | V | I | I | |
| NA 24 | T | M | M | |
| NA 40 | Y | Y | Q | A′ |
| NA 147 | D | D | N | C′ |
| NA 172 | K | R | R | |
| NA 216 | S | G | G | |
| NA 265 | T | I | I | |
| NA 332 | S | F | F | F′ |
| NA 339 | D | N | D | F′ |
| NA 399 | D | E | E | |
| NA 401 | D | G | G | K′ |
| NA 402 | N | N | S | K′ |
| NA 412 | V | I | V | |
| NA 431 | N | K | K | |
| NA 432 | Q | E | E | |
| NA 435 | E | K | K | |
| NA 437 | L | W | W |
a
Numbering is based on defining the first amino acid of the open reading frame of each gene as amino acid 1.
b
A/Swine/Ontario/52156/03 is a wholly human H1N2 virus.
c
A/Swine/Ontario/48235/04 and A/Swine/Ontario/55383/04 are reassortant viruses with HA, NA, and PBI genes of human influenza virus lineages and the remaining genes of classical swine virus lineage.