TABLE 2.
Drug susceptibility test results of phase Ia
Drug and concn (μg/ml) | No. of strains for which the indicated concn is the MIC
|
Total no. (%) of tests
|
||||||
---|---|---|---|---|---|---|---|---|
Site 1
|
Site 2
|
Site 3
|
||||||
MGIT | 460 | MGIT | 460 | MGIT | 460 | MGIT | 460 | |
Amikacin | ||||||||
≤0.5 | 10 | 10 | 10 | 10 | 10 | 10 | 30 (100) | 30 (100) |
1.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
2.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Capreomycin | ||||||||
0.625 | 1 | 3 | 9 | 10 | 0 | 10 | 10 (33.3) | 23 (76.7) |
1.25 | 8 | 7 | 1 | 0 | 10 | 0 | 19 (63.3) | 7 (23.3) |
2.5 | 1 | 0 | 0 | 0 | 0 | 0 | 1 (3.3) | 0 |
Ethionamide | ||||||||
≤0.625 | 3 | 5 | 7 | 8 | 6 | 8 | 16 (53.3) | 21 (70.0) |
1.25 | 4 | 2 | 0 | 1 | 2 | 1 | 6 (20.0) | 4 (13.3) |
2.5 | 2 | 3 | 1 | 0 | 1 | 0 | 4 (13.3) | 3 (10.0) |
>2.5 | 1 | 0 | 2 | 1 | 1 | 1 | 4 (13.3) | 2 (6.7) |
Ofloxacin | ||||||||
≤1.0 | 10 | 10 | 10 | 10 | 10 | 10 | 30 (100) | 30 (100) |
2.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
4.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Rifabutin | ||||||||
≤0.25 | 10 | 10 | 10 | 10 | 10 | 10 | 30 (100) | 30 (100) |
0.5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
1.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Linezolid | ||||||||
≤0.5 | 5 | 5 | 5 | 10 | 10 | 8b | 20 (66.7)b | 23 (76.7)b |
1.0 | 5 | 5 | 4 | 0 | 0 | 1 | 9 (30.0) | 6 (20.0) |
2.0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 (3.3) | 0 |
Ten strains were tested. MGIT, MGIT 960; 460, BACTEC 460.
Results for one test missing.