TABLE 3.
Clinical characteristics of patients infected with genotype C HBV isolates with different configurations at nucleotides 1856 to 1858a
| Characteristic | TCC (n = 67) | CCC (n = 79) | P value for TCC vs CCC | CCT (n = 62) | P value for TCC vs CCT |
|---|---|---|---|---|---|
| Age (yr)c | 38 ± 15 | 38 ± 12 | 0.60 | 41 ± 12 | 0.41 |
| No. (%) male | 44 (66) | 56 (71) | 0.50 | 31 (50) | 0.071 |
| No. (%) with previous antiviral treatment | 4 (6) | 2 (3) | 0.44 | 2 (3) | 0.64 |
| No. (%) HBeAg positive | 39 (58) | 43 (54) | 0.65 | 22 (36) | 0.01 |
| No. (%) with cirrhosis | 12 (18) | 4 (5) | 0.013 | 8 (13) | 0.43 |
| Log HBV DNA level (no. of copies/ml)c | 6.56 ± 1.92 | 6.47 ± 1.91 | 0.77 | 6.12 ± 1.92 | 0.20 |
| No. (%) with HBV DNA level >10,000 copies/ml | 60 (90) | 72 (91) | 0.75 | 51 (82) | 0.23 |
| ALT level (range)d | 65 (13-1,011) | 62 (14-710) | 0.37 | 49 (17-753) | 0.006 |
| No. (%) with ALT level: | |||||
| Normal | 29 (43) | 37 (47) | 36 (58) | ||
| One to two times ULNb | 16 (24) | 27 (34) | 0.22 | 18 (29) | 0.044 |
| Two to five times ULN | 15 (22) | 9 (11) | 7 (11) | ||
| More than five times ULN | 7 (11) | 6 (8) | 1 (2) |
a
As the number of patients with CTC at nucleotides 1856 to 1858 was small, the clinical features of patients harboring HBV with TCC were compared to those harboring HBV with CCC and CCT.
b
ULN, upper limit of normal.
c
Values are means ± SD.
d
Values are in international units per liter.