TABLE 5.
Correlation of SSCP patterns with nucleotide sequences and amino acid substitutions in parE compared to that of S. pneumoniae R6
| SSPC pattern | Description of patternb | No. isolates (%) | MIC range (μg/ml)a
|
460d
|
476d
|
|||
|---|---|---|---|---|---|---|---|---|
| CIP | LEV | nte | aaf | nt | aa | |||
| 1c | R6 | 4 (4) | 4-16 | 1-2 | ATC | Ile | ATC | Ile |
| 2 | 1 sub + 1 var | 54 (54) | 4-32 | 0.5->16 | G-- | Val | --T | |
| 3 | 1 sub | 42 (42) | 4-64 | 1-16 | G-- | Val | ||
a
CIP, ciprofloxacin; LEV, levofloxacin.
b
sub, no. of amino acid substitution; var, no. of base pair variation compared to R6.
c
S. pneumoniae R6 strain.
d
Numeral indicates amino acid position. nt, nucleotide; aa, amino acid.
e
Nucleotide sequence change relative to S. pneumoniae R6.
f
Amino acid substitution corresponding to nt change.