FIG. 1.

Catabolic pathways and proposed functions of the atu and liu cluster products from P. aeruginosa PAO1. (A and B) Upper and lower pathways of acyclic monoterpene catabolism; (C and D) Upper and lower pathways of leucine catabolism. AtuD, citronellyl-CoA dehydrogenase; AtuC/AtuF, geranyl-CoA carboxylase; AtuE, γ-carboxygeranyl-CoA hydratase; LiuE, 3-hydroxy-γ-carboxygeranyl-CoA and 3-hydroxy-3-methylglutaryl-CoA lyase; I, leucine transaminase; II, 2-ketoisocaproic dehydrogenase; LiuA, isovaleryl-CoA dehydrogenase; LiuB/LiuD, 3-methylcrotonyl- CoA carboxylase; LiuC, 3-methylglutaconyl-CoA hydratase. (Adapted from references 5, 9, 12, and 26.)