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Distribution of substitutions affecting termination. (A) Substitutions in eukaryotic RNAP affecting termination and located near the lobe, funnel, and fork domains and switches have been mapped onto the structure of S. cerevisiae RNAP II. (B) Substitutions in prokaryotic RNAP affecting termination and located near the lobe, funnel, and fork domains and switches have been mapped onto the structure of T. aquaticus RNAP.
