FIG. 8.
Sphingolipid biosynthesis in yeast. The yeast sphingolipid biosynthetic pathway indicating the steps blocked by sur1, sur2, sur4, fen1/sur5, and ipt1 mutations that suppress the phenotypes of rvs161 and rvs167 mutants. CoA, coenzyme A; LCB, long-chain base; PI, phosphatidylinositol; Inos-P, inositol-1-P; Cer, ceramide; IPC, inositolphosphorylceramide; MIPC, mannosyl-inositolphoshorylceramide; M(IP)2C, mannosyl-diinositolphoshorylceramide; Man-P-Inos, mannose(α-1,2)inositol-1-P. (Reprinted from reference 54 with permission from Elsevier.)