TABLE 2.
Nomenclature of various BAR domain proteins and their splice variantsa
| Type | Nameb (reference) | Other name(s) | Exon(s) missing | Remarks |
|---|---|---|---|---|
| Different amphiphysin 1 isoforms | Amphiphysin 1 (or I) isoform 1 (47) | Longer amphiphysin isoform expressed in brain. | ||
| Amphiphysin 1 (or I) isoform 2 (77) | Shorter amphiphysin isoform expressed in brain. Also detected in breast carcinoma. | |||
| Amphiphysin 1 (or I) (326) | Retina-specific amphiphysin isoform, contains two novel insertions. | |||
| Different BIN1/amphiphysin 2/amphiphyin II/Amph2/BRAMP2/SH3p9/ALP1/ amphiphysin IIm isoforms | BIN1-iso1 (245)1 | Amphiphysin IIa (255); S11/R3-a; BRAMP2 (168) | 10 | Expressed in brain and concentrated in nerve terminals. Localizes to the cytoplasm. |
| BIN1-iso2 (245)1 | Amphiphysin IId (255); S11/R3-b | 10; 12a | Expressed in brain. Localizes to the cytoplasm and nucleus. | |
| BIN1-iso3 (245)1 | Amphiphysin IIc1 (255) | 10; 12 (a, b, c) | Expressed in brain. Localizes to the cytoplasm and nucleus. | |
| BIN1-iso4 (245)2 | 6a; 12 (b, c, d) | Expressed in brain and possibly in muscle. Localizes to the cytoplasm and nucleus. | ||
| BIN1-iso5 (245)3 | Amphiphysin IIb (255) | 6a; 10; 12 (b, c) | Expressed in brain. Localizes to the cytoplasm and nucleus. | |
| BIN1-iso6 (245)3 | AP II2 (338) | 6a; 10; 12 (b, c, d) | Expressed in brain. Localizes to the cytoplasm and nucleus. Aberrantly expressed in melanoma (93). | |
| BIN1-iso7 (245)3 | Amphiphysin IIc2 (255) | 6a; 10; 12 (a, b, c) | Expressed in brain. Localizes to the cytoplasm and nucleus. | |
| BIN1-iso8 (245)2 | Amph 2-7 (369) | 6a; 12 (a, b, c, d) | Expressed in muscle and localizes to the nucleus. | |
| BIN1-iso9 (245)4 | BIN1-10 (356); SH3P9 (306); AP II3 (338) | 6a; 10; 12 (a, b, c, d) | Ubiquitously expressed. | |
| BIN1-iso10 (245)5 | BIN1-10-13 (356); ALP1 (141); amphiphysin IIm (100); Amph 2-6 (369) | 6a; 10; 12 (a, b, c, d); 13 | Ubiquitously expressed, the only Amph II/Bin1 isoform in macrophages. | |
| BIN1-iso11 | Amph 2-1 (369) | 10; 13 | Expressed in brain. | |
| BIN1-iso12 | Amph 2-2 (369) | 10; 12d; 13 | Expressed in brain. | |
| BIN1-iso13 | Amph 2-3 (369) | 10; 12 (a, b, c, d); 13; 14; 15; 16 | Expressed in brain, lacks SH3 domain. | |
| BIN1-iso14 | Amph 2-4 (369) | 6a; 10; 11; 12 (a, b, c, d); 13; 14; 15; 16 | Expressed in brain, lacks SH3 domain. | |
| BIN1-iso15 | Amph 2-5 (369) | 10; 12 (a, b, c, d); 13 | Expressed in brain. | |
| Endophilin family proteins | Endophilin A1 (134) | Endophilin 1 (323); SH3P4 (323); SH3GL2 (99); EEN-B1 (304) | Expressed mainly in brain. | |
| Endophilin A2 (134) | Endophilin 2 (323); SH3P8 (323); SH3GL1 (99); EEN (304) | Ubiquitously transcribed (270), but only translated in brain and testis (269). | ||
| Endophilin A3 (134) | Endophilin 3 (323); SH3P13 (323); SH3GL3 (99); EEN-B2 (304) | Expressed mainly in brain and testis. | ||
| Endophilin B1 (134) | SH3GLB1 (244); Bif-1 (43) | Expressed mainly in heart, placenta, and skeletal muscle, cytoplasmic protein. | ||
| Endophilin B2 (134) | SH3GLB2 (244) | Expressed mainly in heart, placenta, and skeletal muscle, cytoplasmic protein. |
This table adopts the Bin1 exon nomenclature proposed by Wechsler-Reya et al. (356); however, one additional missing exon located between exons 6 and 7 is referred to here as exon 6a. In the recently introduced systematic nomenclature, exon 6a is renamed exon 7 and the following exons have been assigned new numbers (n + 1) with respect to the exon numbers referred to here and in the previous literature reports. The new systematic Bin1 splice isoform nomenclature and some of the exon information shown in this table was obtained from the National Center for Biotechnology Information and the U.S. National Library of Medicine, Bethesda, Md., via the following internet URL: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=full_report&list_uids=274.
Superscript numbers are as follows: 1, Bin1+6a+12+13 in the text; 2, Bin1+10+13 in the text; 3, Bin1−6a+12+13 in the text; 4, Bin1−10−12+13 in the text; 5, Bin1−10−12−13 in the text. Note: Bin1+12+13 in the text refers collectively to Bin1−6a+12+13 and Bin1+6a+12+13; Bin1+12 in the text refers collectively to Bin1−6a+12+13, Bin1+6a+12+13, Bin1−6a+12−13, and Bin1+6a+12−13; Bin1+10 in the text refers collectively to Bin1+10−13 and Bin1+10+13.