Figure 3.

Structural Similarity in the EMF2/Su(z)12 Protein Family.

(A) Schematic comparison of EMF2, VRN2, FIS2, Su(z)12, and KIAA1610 protein structures. Conserved N-terminal basic domains, C₂H₂-type zinc finger domains, and C-terminal acidic-W/M domains are colored blue, green, and pink, respectively.

(B) to (D) Sequence alignment of the proteins. Identical amino acids and similar amino acids are boxed in red and yellow, respectively. con, consensus sequence.

(B) Sequence alignment in N-terminal basic domains. Basic amino acid clusters are indicated by a blue bar.

(C) Sequence alignment in zinc finger regions. Conserved cysteine and histidine residues involved in zinc finger formation are indicated with green circles.

(D) Sequence alignment in acidic-W/M domains. Acidic amino acid clusters are indicated by a pink bar.