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Distribution of p-values for the comparison of RNA from 3 murine with homozygous PKDH mutations and a high kidney length-to-width ratio and RNA from 3 mice with homozygous PKDH mutations and a low kidney length-to-width ratios. The dotted Blue line is the expected distribution of p-values if the treatment has no effect and the solid Green line is the mixed-model [23] fit of the p-value constrained to be monotonically non-decreasing.
